宋恒，教授，博士生导师，
国家海外高层次人才引进计划，武汉大学弘毅青年学者，
湖北省高层次人才，
“3551光谷人才计划”，
研究方向化学生物学、合成生物学和酶催化。
教育与研究经历：
2018至今 教授、博导，
武汉大学化学与分子科学学院
2015 – 2018 博士后，劳伦斯伯克利国家实验室和加州大学伯克利分校
2010 – 2015 博士，波士顿大学化学系
2005 – 2009 学士，南京大学化学系
研究领域与兴趣
：化学生物学、合成生物学、生物工程、酶催化、小分子探针在生物过程中的检测应用、蛋白工程改造、代谢工程生产、生物信息学和化学信息学。
获资助项目
：
2025-深圳市自然科学基金面上项目
2025-国家发改委绿色生物制造项目
2024-
广东省自然科学基金面上项目
2023-国家自然科学基金面上项目
2023-入选 湖北省高层次人才
2022-共同药业[股票300966]高级科学家顾问
2022-入选“3551光谷人才计划”
2022-广东省自然科学基金面上项目
2021-入选“南鄂英才计划”
2020-国家自然科学基金青年项目
2019-科技部重点研发计划纳米专项青年项目课题负责
2019-科技部重点研发计划合成生物学专项子课题负责
2018- 武汉大学引进人才项目， 国家海外高层次人才引进计划
欢迎有志于合成生物学和化学生物学以及生物工程方向的、致力于复合型学科研究的青年才俊前来交流、切磋和学习；欢迎参加武汉大学“
优秀大学生暑期夏令营
”的同学咨询宋老师实验室相关情况；欢迎优秀学子报考宋老师化学和生物学交叉方向实验室的
推免研究生、博士生和研究生
。
此外，因研究工作需要，实验室
长期招募优秀的博士后研究员（年薪25-40万,上不封顶）和研究助理（年薪8万以上）
，享受武汉大学相关福利政策，待遇非常优厚，欢迎来信垂询。
课题组发表
：
1.
Shuo Zheng, Zixuan Yang, Xiang Long, Xinying Ge, Zhiqin Zhang, Yinyin Feng], Yangyizhuo Li, Bo Gu, Yan Long, Xuanliang Yang, Rui Xu,
Heng Song*
，Chemoenzymatic Synthesis and Protein Engineering Enable Efficient, Scalable Production of Teleocidin Derivatives,
Angewandte Chemie International Edition, 2025, In Press
.
2. Yongze Xie#, Dong-Sheng Yang#, Li-Gang Bai, Jin-wei Yang, Bo Gu, Meng-ting Liu, Qi-Yue Wang, Wang, Wang, Wen-Bo Liu*,
Heng Song*
,
Enantiodivergent access to acyclic quaternary stereocenters by nitrilase-catalyzed desymmetrizing hydrolysis of malononitriles,
Journal of the American Chemical Society
, 2025,
In Press
.
3. Tian Wang, Wenye Cao, Xuemei Wang，Min Dong, Lu Yu, Yinyin Feng, Ning Yang*,
Heng Song*
，Composite synthetic protein hydrogel for inhibition of corneal fibrosis and treatment of corneal wounds,
International Journal of Biological Macromolecules
, 2025, 3072, 142013.
4. Weihua Wang, Han Zhu, Bo Gu, Yongze Xie, Xinlei Xu, Shu-Lin Liu*,
Heng Song*
，Polarity Sensitive and H2O2/Lipid Droplets Sequence-Activated Asymmetric Cyanine Probe Achieves Multi-marker Imaging of Atherosclerosis，
Chinese Journal of Chemistry
, 2025, 43, 1246-1254.
5.
Zhuo-Kun Chen, Shuo Zheng, Yan Long, Kui-Ming Wang, Bo-Lin Xiao, Jin-Bang Li, Wei Zhang*,
Heng Song,*
and Gang Chen*, High-throughput screening identifies ibuprofen as an sEV PD-L1 inhibitor for synergistic cancer immunotherapy,
Molecular Therapy
, 2024, 32, 3580-3596.
6. Shuo Zheng, Xinlei Xu, Tian Gao, and
Heng Song
*,
One-Pot Microbial Cell Factory Strategy for the Production of Protocatechuic Acid from Polyethylene Terephthalate Waste,
ACS Sustainable Chemistry&Engineering
, 2024, 12, 5632-5639.
7. Weihua Wang, Chu Han, Shengjie Xie, Zisong Cong, Zixuan Yang, Yuxin Feng, Limin Xiang,and
Heng Song*
，A High-Contrast Autolysosome Probe for Detecting Interactionbetween Autophagosomes and Autolysosomes in Mitophagy,
Chinese Journal of Chemistry
, 2024, 42, 858-866.
8. Xinying Ge#, Yan Long#, Jun Wang#, Bo Gu, Zixuan Yang, Yinyin Feng, Shuo Zheng, Yingying Li, Wupeng Yan* and
Heng Song
*，Regulation of P450 TleB catalytic flow for the synthesis of sulfur-containing indole alkaloids by substrate structure-directed strategy and protein engineering，
Science China Chemistry
, 2023, 66.
9. Shengbo Li, Xuemei Wang, Zhiyao Yan, Tian Wang, Zhenbing Chen,
Heng Song
* and Yongbin Zheng*, Microneedle Patches with Antimicrobial and Immunomodulating Properties for Infected Wound Healing,
Advanced Science
, 2023, 2300576.
10. Shengjie Xie, Zisong Cong, Weihua Wang, Shanshan Qin, Xiaocheng Weng*,
Heng Song
*, Xiang Zhou, Mitochondria-targeting NIR AIEgens with cationic amphiphilic chaacter for imaging and efficient photodynamic therapy,
Chemical Communication
, 2023, 59, 2592.
11. Zhiqin Xu, Yaling Mo, Zhengwen Li, Shurong Ban* and
Heng Song*
,
New small-molecule alcohol synthesis by breaking the space limitation of the “aromatic cage”in Pseudomonas sp. AK1 BBOX,
Organic Biomolecular Chemistry
, 2023, 21, 6397–6404
12. Zhen Q. Wang#,
Heng Song
#(共同一作), Edward J. Koleski, Noritaka Hara, Dae Sung Park, Gaurav Kumar, Yejin Min, Paul J. Dauenhauer and Michelle C. Y. Chang*，A dual cellular–heterogeneous catalyst strategy for the production of olefins from glucose，
Nature Chemistry
, 2021, 13, 1178–1185.
13. Zhuoran Jiang, Chao Wang, Zixin Wu, Kun Chen, Wei Yang, Hexiang Deng*,
Heng Song*
and Xiang Zhou*, Enzymatic deamination of the epigenetic nucleoside N6-methyladenosine regulates gene expression,
Nucleic Acids Research
, 2021, 49, 12049-12069.
14. Yunbin Wu, Rui Xu, Yuxin Feng,
Heng Song*
,
Rational Design of a De Novo Enzyme Cascade for Scalable Continuous Production of Antidepressant Prodrugs,
ACS Catalysis
, 2022, 12, 3767-3775.
15.
Yan Long#, Shuo Zheng#, Yuxin Feng, Zixuan Yang, Xinlei Xu, and
Heng Song*
, Kinetic Solvent Isotope Effect in P450-Mediated Cyclization in Indolactams: Evidence for Branched Reactions and Guide for Their Modulation in Heterocycle Chemoenzymatic Synthesis,
ACS Catalysis
, 2022, 12, 9857-9863.
16.
Xuemei Wang#, Shengbo Li#, Siqi Wang, Shuo Zheng, Zhenbing Chen*,
Heng Song*
, Protein Binding Nanoparticles as an Integrated Platform for Cancer Diagnosis and Treatment,
Advanced Science
, 2022, 2202453.
17. Zisong Cong#, Shengjie Xie#, Zhuoran Jiang, Shuo Zheng, Weihua Wang, Wenyan Wang and
Heng Song*
, In vivo photodynamic therapy based on Near-Infrared AIE cationic polymers,
Chemical Engineering Journal
, 2022, 431, 133748.
18. Jie Wang#, Zhuoran Jiang#, Yurong Wei#, Wenjie Wang, Fubing Wang, Yanbing Yang*,
Heng Song*
, and Quan Yuan*, Multiplexed identification of bacterial biofilm infections based on machine-learning-aided lanthanide encoding,
ACS Nano
, 2022, 16, 2, 3300–3310.
19. Wenyan Wang, Shuo Zheng, Yinhui Hong, Xinlei Xu, Xiang Feng, and
Heng Song*
, Hydrogel-metal-organic-framework nanoparticle composites for immobilization of active biomacromolecules,
ACS Applied Nano Materials.
2022, 5, 2, 2222–2230.
20. Shengbo Li#, Xuemei Wang#, Jing Chen, Jiahe Guo, Meng Yuan, Gui Wan, Chengqi Yan, Wenqing Li, Hans-Günther Machens,Yuval Rinkevich, XiaofanYang*,
Heng Song*
and Zhenbing Chen*, Calcium ion cross-linked sodium alginate hydrogels containing deferoxamine and copper nanoparticles for diabetic wound healing,
International Journal of Biological Macromolecules
, 2022, 202, 657-670.
21.
Yuxin Feng,# Yan Long,# Jiahe Guo,# Xiaofan Yang* and
Heng Song*,
Redox- and pH-responsive water-soluble flexible organic frameworks realize synergistic tumor photodynamic and chemotherapeutic therapy
,
Macromolecular Rapid Communications,
2022, DOI: 10.1002/marc.202200690.
22. Siqi Wang, Zisong Cong, Zhiqin Xu, Shurong Ban* and
Heng Song*
, Fluorescent dyes with multiple quaternary ammonium centers for specific image discrimination and Gram-positive antibacterial activity,
Organic & Biomolecular Chemistry
. 2022, 20, 3980-3987.
23. Yaxuan Qian#, Zhuoran Jiang#, Yan Long#, Houguo Fei,
Heng Song*
, Cunlan Guo*, Electro-Enzymatic Aromatic Nitration via Electric Field and Electro-mediator,
ACS Sustainable Chemistry&Engineering
, 2022, 10, 6667-6674.
