一提到记忆问题，人们就会想到阿尔茨海默病。但
LATE
跟阿尔茨海默病不一样，它有自己的特点。在某些情况下，可能会有人同时出现
LATE
和阿尔茨海默病的体征和症状。
LATE
患者有记忆力问题，但其临床变化速度通常比阿尔茨海默病患者慢。LATE 患者可能会发现，随着时间的推移，他们会更难记住事实、对话和事件。
LATE
患者可能会经常重复自己的话，健忘，在谈话中很难找到正确的词语。他们可能在理解字词上也有困难。
LATE
患者可能会：
走失或迷路
做出错误决定
把东西放错地方
很难保持个人卫生
最终，
LATE
患者会难以完成穿衣、烹饪或支付账单等日常生活活动。
LATE
患者的智力衰退比其他痴呆症更慢，所以症状是缓慢恶化而不是迅速恶化。
排除其他原因
医务人员可能会检查可能由
LATE
引起的大脑变化，包括大脑萎缩（萎缩）和负责记忆形成的大脑分区变薄的迹象。这些变化可以通过
MRI
检查和尸检看到。与脑组织萎缩相比，脑组织变薄似乎是疾病严重程度的一个更强的指标。
蛋白反式激活应答 DNA 结合蛋白 43（TDP-43）的蓄积可能是
LATE
的另一个体征。这种天然蛋白质有助于神经发育。
TDP-43
通常在大脑掌管记忆、情感、行为和情绪的分区（边缘系统）蓄积。目前没有一种检测可以直接判断一个人的
TDP-43
是否过量，只有通过尸检才能发现。
另一个可能提示
LATE
诊断的体征是动脉壁硬化和增厚（小动脉硬化），这在
LATE
患者中很常见。
如果医务人员怀疑您患有
LATE
，可能会建议您进行精神状态检查，以确认认知损害的严重程度。
研究人员正在努力探索一种更简单的方法来诊断
LATE
和其他类型的痴呆症，以便快速识别这些疾病。研究人员正在努力开发一种针对痴呆症（包括
LATE
）患者的简单血液筛查测试，但目前仍在研究中。
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TDP-43
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TDP-43
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