刘勤, 陶金辉, 马艳, 汪亚玲, 李琳, 陆群群, 张敏, 王雪. 血清抗链球菌溶血素O效价与强直性脊柱炎病情及不同药物治疗影响的关联性研究[J]. 中华疾病控制杂志, 2018, 22(10): 1055-1058,1062. doi: 10.16462/j.cnki.zhjbkz.2018.10.018
引用本文:
刘勤, 陶金辉, 马艳, 汪亚玲, 李琳, 陆群群, 张敏, 王雪. 血清抗链球菌溶血素O效价与强直性脊柱炎病情及不同药物治疗影响的关联性研究[J]. 中华疾病控制杂志, 2018, 22(10): 1055-1058,1062.
doi:
10.16462/j.cnki.zhjbkz.2018.10.018
LIU Qin, TAO Jin-hui, MA Yan, WANG Ya-ling, LI Lin, LU Qun-qun, ZHANG Min, WANG Xue. Study on the association between serum anti-streptolysin O titers and conditions of ankylosing spondylitis or effects of different drug treatments[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2018, 22(10): 1055-1058,1062. doi: 10.16462/j.cnki.zhjbkz.2018.10.018
Citation:
LIU Qin, TAO Jin-hui, MA Yan, WANG Ya-ling, LI Lin, LU Qun-qun, ZHANG Min, WANG Xue. Study on the association between serum anti-streptolysin O titers and conditions of ankylosing spondylitis or effects of different drug treatments[J].
CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION
, 2018, 22(10): 1055-1058,1062.
doi:
10.16462/j.cnki.zhjbkz.2018.10.018
刘勤, 陶金辉, 马艳, 汪亚玲, 李琳, 陆群群, 张敏, 王雪. 血清抗链球菌溶血素O效价与强直性脊柱炎病情及不同药物治疗影响的关联性研究[J]. 中华疾病控制杂志, 2018, 22(10): 1055-1058,1062. doi: 10.16462/j.cnki.zhjbkz.2018.10.018
引用本文:
刘勤, 陶金辉, 马艳, 汪亚玲, 李琳, 陆群群, 张敏, 王雪. 血清抗链球菌溶血素O效价与强直性脊柱炎病情及不同药物治疗影响的关联性研究[J]. 中华疾病控制杂志, 2018, 22(10): 1055-1058,1062.
doi:
10.16462/j.cnki.zhjbkz.2018.10.018
LIU Qin, TAO Jin-hui, MA Yan, WANG Ya-ling, LI Lin, LU Qun-qun, ZHANG Min, WANG Xue. Study on the association between serum anti-streptolysin O titers and conditions of ankylosing spondylitis or effects of different drug treatments[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2018, 22(10): 1055-1058,1062. doi: 10.16462/j.cnki.zhjbkz.2018.10.018
Citation:
LIU Qin, TAO Jin-hui, MA Yan, WANG Ya-ling, LI Lin, LU Qun-qun, ZHANG Min, WANG Xue. Study on the association between serum anti-streptolysin O titers and conditions of ankylosing spondylitis or effects of different drug treatments[J].
CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION
, 2018, 22(10): 1055-1058,1062.
doi:
10.16462/j.cnki.zhjbkz.2018.10.018
目的
探讨血清抗链球菌溶血素O（anti-streptolysin O，ASO）效价与强直性脊柱炎（ankylosing spondylitis，AS）疾病活动关联性，分析不同药物治疗对ASO效价的影响。
方法
采取回顾性队列研究，收集AS患者治疗前后血清ASO、血沉（erythrocyte sedimentation rate，ESR）、C反应蛋白（c-reactive protein，CRP）、血白细胞（white blood cell，WBC）、血小板（platelet，PLT）、免疫球蛋白（immunoglobulin，Ig）以及治疗用药资料。分析AS不同时期血清ASO效价与ESR、CRP、WBC、PLT、Ig关联性，评估病情活动、不同药物对ASO效价的影响。
结果
1 946例入选AS患者中，926例检测了血清ASO，效价升高者244例，ASO阳性率为26.35%。其中43例患者治疗后定期复查了2次ASO及相关指标。治疗前血清ASO效价与ESR、CRP均有正相关，差异具有统计学意义（均有
P
<0.05）；治疗后ASO效价降低，差异有统计学意义（χ
2
=51.907，
P
<0.001）；其中未用长效青霉者和使用长效青霉者治疗后ASO效价均显著降低，治疗前后三组间差异均有统计学意义（χ
2
=11.711，
P
=0.003；χ
2
=7.042，
P
=0.030），且使用长效青霉素者比未用者ASO效价降低更明显，两组间差异有统计学意义（
F
=3.404，
P
=0.049）。
结论
AS治疗前血清ASO效价与病情活动有关，治疗后效价降低，抗感染治疗降低程度更明显。
强直性脊柱炎 /
抗链球菌溶血素O /
长效青霉素 /
Abstract:
Objective
To investigate the relationship between serum anti-streptolysin O (ASO) titers and ankylosing spondylitis (AS) disease activity and to analyze the effect of different drug treatments on ASO titers.
Methods
A retrospective cohort study was conducted to collect serum ASO, ESR, C-reactive protein (CRP), white blood cells (WBC), platelets (PLT), immunoglobulin (Ig) and therapeutic data before and after treatment in AS patients. The relationship between serum ASO titer and ESR, CRP, WBC, PLT and Ig in different stages of AS was analyzed to assess the influence of disease activity and different therapeutic drugs on serum ASO titer.Results Of the 1946 patients enrolled in AS, serum ASO was detected in 926 patients, and 244 patients were found to have elevated ASO titer, with a positive rate of 26.35%. Of these, 43 patients regularly reviewed ASO and related indicators more than twice after treatment. Serum ASO titers were positively correlated with ESR and CRP before treatment (all
P
<0.05); Serum ASO titer decreased significantly after treatment and the difference was statistically significant (χ
2
=51.907,
P
<0.001); The ASO titer was significantly decreased in those who did not use long-acting penicillium and use long-acting penicillus, the differences between the three groups were statistically significant before and after treatment (χ
2
=11.711,
P
=0.003; χ
2
=7.042,
P
=0.030), and the long-acting penicillin had a more pronounced decrease in the ASO titer than the non-user, the difference between the two groups was statistically significant (
F
=3.404,
P
=0.049).
Conclusion
The serum ASO titer was related to the disease activity before AS treatment, the ASO titer was significantly reduced after treatment, and the ASO titer may reduce more significant with the anti-infective treatment.
Key words:
Ankylosing spondylitis /
Anti-streptolysin O /
Long-acting penicillin /
Anti-infection
