DNA修复基因多态性在六价铬遗传损伤中的作用

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Abstract: Exposure to hexavalent chromiumCr (Ⅵ) can lead to the injury of respiratory, digestive, skin, and other systems or organs, and even induce cancers, which is a serious threat to health. Human repair system can mend the damage in time and maintain the stability of genome. Recent studies have pointed out that given the widespread presence of polymorphisms in DNA repair genes, individuals with the same Cr (Ⅵ) exposure show significant differences in DNA repair capacity, which results in an interindividual difference in the genetic damage induced by Cr (Ⅵ). These findings provide us a new research direction for the prevention and screening of high-risk group susceptible to Cr (Ⅵ) exposure. In order to understand the latest research progress about the role of DNA repair gene polymorphisms in the susceptibility of genetic damage induced by Cr (Ⅵ), the article reviewed relevant domestic and international literatures in recent five years on DNA damage caused by Cr (Ⅵ), repair mechanism, and related repair genes and their polymorphisms.

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