治疗前, 血清Ghrelin、胃体黏膜Ghrelin、GHS-R比较, 差异无统计学意义(
P
>0.05); 治疗后, 2组血清Ghrelin含量、胃体黏膜Ghrelin、GHS-R与治疗前比较增高显著, 差异有统计学意义(
P
<0.05); 治疗后2组同一时间点Ghrelin含量比较, 差异有统计学意义(
P
<0.05); 采用Spearman相关性分析, 结果显示, 血清Ghrelin与胃体黏膜Ghrelin、GHS-R表达呈正相关(
P
= 0.002,
P
= 0.001).
引文著录:
谢胜, 侯秋科, 周晓玲, 朱初良, 张志杰, 赵正孝, 晁梁, 杨得志, 蒋应玲, 郭庆, 韦金秀. 周易象数切脉疗法对功能性消化不良患者Ghrelin、GHS-R分子表达变化的影响.
世界华人消化杂志
2017; 25(19): 1750-1756
Effect of Zhouyi Xiangshu Qiemai therapy on expression of ghrelin and GHS-R in gastric mucosa of patients with functional dyspepsia
Sheng Xie, Qiu-Ke Hou, Xiao-Ling Zhou, Chu-Liang Zhu, Zhi-Jie Zhang, Zheng-Xiao Zhao, Liang Chao, De-Zhi Yang, Ying-Ling Jiang, Qing Guo, Jin-Xiu Wei
Sheng Xie,
Department of Spleen and Stomach Diseases, the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530023, Guangxi Zhuang Autonomous Region, China
Qiu-Ke Hou,
the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, Guangdong Province, China
Xiao-Ling Zhou, Chu-Liang Zhu, Zhi-Jie Zhang, Zheng-Xiao Zhao, Liang Chao, De-Zhi Yang, Ying-Ling Jiang, Qing Guo, Jin-Xiu Wei,
the Third Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Liuzhou 545000, Guangxi Zhuang Autonomous Region, China
Supported by
:
Guangxi Natural Science Foundation
, No.
2013GXNSFAA019232
.
Correspondence to
: Qiu-Ke Hou, Attending Physician, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, 16 Jichang Road, Guangzhou 510405, Guangdong Province, China.
[email protected]
Received:
April 17, 2017
Revised:
May 14, 2017
Accepted:
May 22, 2017
Published online:
July 8, 2017
AIM
To observe the effect of Zhouyi Xiangshu Qiemai therapy on the expression of ghrelin and growth hormone secretagogue recepter (GHS-R) in the gastric mucosa of patients with functional dyspepsia (FD).
METHODS
Eighty FD patients were divided into either an observation group or a control group, with 40 patients in each group. The observation group was treated with Zhouyi Xiangshu Qiemai therapy, and the control group was treated with mosapride citrate dispersible tablets. Serum levels of ghrelin were detected before and 7 d, 14 d and 21 d after treatment. The expression of ghrelin and GHS-R in the gastric mucosa was also detected.
RESULTS
Before treatment, serum level of ghrelin and the expression of ghrelin and GHS-R in the gastric mucosa did not differ significantly between the two groups (
P
> 0.05). After treatment, serum levels of ghrelin and the expression of ghrelin and GHS-R in the gastric mucosa in both groups were significantly higher than those before treatment (
P
< 0.05), and serum level of ghrelin differ significantly between the two groups at the same time points (
P
< 0.05). Spearman correlation analysis showed that serum ghrelin was positively correlated with ghrelin and GHS-R expression in the gastric mucosa (
P
= 0.002,
P
= 0.001).
CONCLUSION
Zhouyi Xiangshu Qiemai therapy exerts its therapeutic effect in patients with functional dyspepsia possibly by up-regulation of ghrelin release and ghrelin/GHS-R expression in the gastric mucosa.
Key Words:
Zhouyi Xiangshu Qiemai therapy; Functional dyspepsia; Ghrelin; GHS-R; Gastric mucosa
Citation:
Xie S, Hou QK, Zhou XL, Zhu CL, Zhang ZJ, Zhao ZX, Chao L, Yang DZ, Jiang YL, Guo Q, Wei JX. Effect of Zhouyi Xiangshu Qiemai therapy on expression of ghrelin and GHS-R in gastric mucosa of patients with functional dyspepsia.
Shijie Huaren Xiaohua Zazhi
2017; 25(19): 1750-1756
URL:
https://www.wjgnet.com/1009-3079/full/v25/i19/1750.htm
DOI:
https://dx.doi.org/10.11569/wcjd.v25.i19.1750
