陈琳
，
博士
，
教授，广州医科大学南山学者骨干人才，博士毕业于中国科学院生物物理研究所，之后加入药企从事细胞治疗相关研发工作，
2018
年加入广州医科大学生科院。发表多篇第一作者文章，包括
Journal of Hepatology, Cancer Research, American Journal of Pathology
等，合计影响因子大于
30
分，有丰富的肿瘤免疫和细胞治疗领域研究经验，同时具备临床细胞治疗产品开发经验。
研究方向：
宫颈癌等妇科肿瘤的
T
细胞免疫治疗机制研究
宫颈癌等妇科肿瘤的
T
细胞免疫治疗方法的开发
免疫检查点抗体与其他治疗方法的联合用药
过往研究经历：
1.T
细胞肿瘤免疫治疗研究：
T
细胞肿瘤免疫治疗靶点的发现
TCR-T
用于治疗肿瘤的体内药效学研究及安全性评价
2.肿瘤微环境研究：
S100A4
阳性巨噬细胞在早期肝癌及肝纤维化中的作用
Tie2
阳性巨噬细胞在肿瘤化疗后复发中的作用
Publications:
1.-Wang C, Xiong C, Hsu Y, Wang X,
Chen L
. Human leukocyte antigen (HLA) and cancer immunotherapy: HLA-dependent and -independent adoptive immunotherapies. Ann Blood [Internet]. 2020;5:14–14. Available from: http://aob.amegroups.com/article/view/5744/html
2.-Li Q, Dai C, Xue R, Wang P,
Chen L,
Han Y, et al. S100A4 protects myeloid-derived suppressor cells from intrinsic apoptosis via TLR4-ERK1/2 signaling. Front Immunol. 2018;9:1–14.
3.-
Chen L
, Li J, Wang F, Dai C, Wu F, Liu X, et al. Tie2 expression on macrophages is required for blood vessel reconstruction and tumor relapse after chemotherapy. Cancer Res. 2016;76:6828–38.
4.-
Chen L
, Li J, Zhang J, Dai C, Liu X, Wang J, et al. S100A4 promotes liver fibrosis via activation of hepatic stellate cells. J Hepatol [Internet]. European Association for the Study of the Liver; 2015;62:156–64. Available from: http://dx.doi.org/10.1016/j.jhep.2014.07.035
5.- Sun L, Sun C, Liang Z, Li H,
Chen L
, Luo H, et al. FSP1+fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells. Sci Rep [Internet]. Nature Publishing Group; 2015;5:1–16. Available from: http://dx.doi.org/10.1038/srep14871
6.- Zhang J,
Chen L
, Liu X, Kammertoens T, Blankenstein T, Qin Z. Fibroblast-specific protein 1/S100A4-positive cells prevent carcinoma through collagen production and encapsulation of carcinogens. Cancer Res. 2013;73:2770–81.
7.-Li J,
Chen L
, Qin Z. Multifaceted tumor stromal fibroblasts. Cancer Microenviron. 2012;5:187–93.
8.-Zhang J,
Chen L
, Xiao M, Wang C, Qin Z. FSP1+fibroblasts promote skin carcinogenesis by maintaining MCP-1-mediated macrophage infiltration and chronic inflammation. Am J Pathol [Internet]. Elsevier Inc.; 2011;178:382–90. Available from: http://dx.doi.org/10.1016/j.ajpath.2010.11.017
9.-Li Z,
Chen L
, Qin Z. Paradoxical Roles of IL-4 in Tumor Immunity The paradox of IL-4 in tumor immunity. Cell Mol Immunol [Internet]. 2009;2. Available from: https://www.nature.com/articles/cmi200953.pdf
