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小百科  ›  Lomustine (CCNU,洛莫司汀) - 仅供科研| DNA Alkylator/Crosslinker ...
络莫 cell 生物技术
从未表白的眼镜
1 年前
  • Anti-infection 抗感染
  • ADC Related 抗体偶联药物相关
  • Apoptosis 凋亡
  • Autophagy 自噬
  • Cell Cycle/DNA Damage 细胞周期/DNA 损伤
  • Cytoskeleton 细胞骨架
  • Epigenetics 表观遗传学
  • GPCR/G Protein G 蛋白偶联受体/G 蛋白
  • Immunology/Inflammation 免疫及炎症
  • JAK/STAT Signaling JAK/STAT 信号通路
  • MAPK/ERK Pathway MAPK/ERK 信号通路
  • Membrane Transporter/Ion Channel 跨膜转运
  • Metabolic Enzyme/Protease 代谢酶/蛋白酶
  • Neuronal Signaling 神经信号通路
  • NF-κB NF-κB 信号通路
  • PI3K/Akt/mTOR PI3K/Akt/mTOR 信号通路
  • PROTAC 蛋白降解靶向嵌合体
  • Protein Tyrosine Kinase/RTK 蛋白酪氨酸激酶
  • Stem Cell/Wnt 干细胞及 Wnt 通路
  • TGF-beta/Smad TGF-beta/Smad 信号通路
  • Vitamin D Related/Nuclear Receptor 维生素 D 相关/核受体
  • Others 其他
Anti-infection
  • Antibiotic
  • Arenavirus
  • Bacterial
  • CMV
  • EBV
  • Enterovirus
  • Filovirus
  • Fungal
  • HBV
  • HCV
  • HCV Protease
  • HIV
  • HIV Protease
  • HPV
  • HSV
  • Influenza Virus
  • Orthopoxvirus
  • Parasite
  • RABV
  • Reverse Transcriptase
  • RSV
  • SARS-CoV
  • More...
Antibody-drug Conjugate/ADC Related
  • ADC Antibody
  • ADC Cytotoxin
  • ADC Linker
  • Antibody-Drug Conjugates (ADCs)
  • Drug-Linker Conjugates for ADC
  • PROTAC-Linker Conjugates for PAC
Apoptosis
  • Apoptosis
  • Bcl-2 Family
  • c-Myc
  • Caspase
  • DAPK
  • Ferroptosis
  • FKBP
  • IAP
  • MDM-2/p53
  • Necroptosis
  • PKD
  • Pyroptosis
  • RIP kinase
  • Survivin
  • Thymidylate Synthase
  • TNF Receptor
Autophagy
  • Atg4
  • Autophagy
  • Beclin1
  • FKBP
  • LRRK2
  • Mitophagy
  • ULK
Cell Cycle/DNA Damage
  • Antifolate
  • APC
  • ATF6
  • ATM/ATR
  • Aurora Kinase
  • Casein Kinase
  • CDK
  • Checkpoint Kinase (Chk)
  • CRISPR/Cas9
  • Cyclin G-associated Kinase (GAK)
  • Deubiquitinase
  • DNA Alkylator/Crosslinker
  • DNA Stain
  • DNA-PK
  • DNA/RNA Synthesis
  • Early 2 Factor (E2F)
  • Eukaryotic Initiation Factor (eIF)
  • G-quadruplex
  • Haspin Kinase
  • HDAC
  • HSP
  • IRE1
  • More...
Cytoskeleton
  • Arp2/3 Complex
  • Dynamin
  • Gap Junction Protein
  • Integrin
  • Kinesin
  • Microtubule/Tubulin
  • Mps1
  • Myosin
  • PAK
  • ROCK
Epigenetics
  • AMPK
  • Aurora Kinase
  • DNA Methyltransferase
  • Epigenetic Reader Domain
  • HDAC
  • Histone Acetyltransferase
  • Histone Demethylase
  • Histone Methyltransferase
  • JAK
  • Methionine Adenosyltransferase (MAT)
  • METTL3
  • MicroRNA
  • PARP
  • PKC
  • Protein Arginine Deiminase
  • Sirtuin
  • Small Interfering RNA (siRNA)
  • TET Protein
GPCR/G Protein
  • 5-HT Receptor
  • Adenylate Cyclase
  • Adrenergic Receptor
  • Amylin Receptor
  • Angiotensin Receptor
  • Apelin Receptor (APJ)
  • Arrestin
  • Bombesin Receptor
  • Bradykinin Receptor
  • Cannabinoid Receptor
  • CaSR
  • CCR
  • CGRP Receptor
  • Cholecystokinin Receptor
  • CRFR
  • CXCR
  • EBI2/GPR183
  • Endothelin Receptor
  • Formyl Peptide Receptor (FPR)
  • Free Fatty Acid Receptor
  • G protein-coupled Bile Acid Receptor 1
  • G Protein-coupled Receptor Kinase (GRK)
  • More...
Immunology/Inflammation
  • AIM2
  • ALCAM/CD166
  • AP-1
  • Arginase
  • Aryl Hydrocarbon Receptor
  • BCL6
  • CCR
  • CD19
  • CD2
  • CD20
  • CD22
  • CD28
  • CD3
  • CD38
  • CD6
  • CD73
  • Complement System
  • COX
  • CTLA-4
  • CX3CR1
  • CXCR
  • Cyclic GMP-AMP Synthase
  • More...
JAK/STAT Signaling
  • EGFR
  • JAK
  • Pim
  • STAT
MAPK/ERK Pathway
  • ERK
  • JNK
  • KLF
  • MAP3K
  • MAP4K
  • MAPKAPK2 (MK2)
  • MEK
  • Mixed Lineage Kinase
  • MNK
  • p38 MAPK
  • Raf
  • Ribosomal S6 Kinase (RSK)
Membrane Transporter/Ion Channel
  • Apical Sodium-Dependent Bile Acid Transporter
  • Aquaporin
  • ATP Synthase
  • BCRP
  • Calcium Channel
  • Calmodulin
  • CFTR
  • Chloride Channel
  • CRAC Channel
  • CRM1
  • EAAT
  • FATP
  • Ferroportin
  • GABA Receptor
  • GLUT
  • GlyT
  • HCN Channel
  • iGluR
  • Monoamine Transporter
  • Monocarboxylate Transporter
  • Na+/Ca2+ Exchanger
  • Na+/H+ Exchanger (NHE)
  • More...
Metabolic Enzyme/Protease
  • 11β-HSD
  • 15-PGDH
  • 17β-HSD
  • 5 alpha Reductase
  • Acetolactate Synthase (ALS)
  • Acetyl-CoA Carboxylase
  • Acyltransferase
  • Adiponectin Receptor
  • Aldehyde Dehydrogenase (ALDH)
  • Aldose Reductase
  • Aminoacyl-tRNA Synthetase
  • Aminopeptidase
  • Amylases
  • Angiotensin-converting Enzyme (ACE)
  • Arginase
  • ATGL
  • ATP Citrate Lyase
  • Carbonic Anhydrase
  • Carboxypeptidase
  • Cathepsin
  • Ceramidase
  • CETP
  • More...
Neuronal Signaling
  • 5-HT Receptor
  • AAK1
  • Adrenergic Receptor
  • Amyloid-β
  • Beta-secretase
  • Calcium Channel
  • CaMK
  • Cannabinoid Receptor
  • CGRP Receptor
  • Cholecystokinin Receptor
  • Cholinesterase (ChE)
  • COMT
  • FAAH
  • GABA Receptor
  • Glucosylceramide Synthase (GCS)
  • GlyT
  • GPR119
  • GPR139
  • GPR55
  • Histamine Receptor
  • Huntingtin
  • iGluR
  • More...
NF-κB
  • IKK
  • Keap1-Nrf2
  • MALT1
  • NF-κB
  • RANKL/RANK
  • Reactive Oxygen Species
PI3K/Akt/mTOR
  • Akt
  • AMPK
  • ATM/ATR
  • DNA-PK
  • GSK-3
  • MELK
  • mTOR
  • PDK-1
  • PI3K
  • PI4K
  • PIKfyve
  • PTEN
PROTAC
  • ATTECs
  • AUTACs
  • E3 Ligase Ligand-Linker Conjugates
  • Ligands for E3 Ligase
  • Ligands for Target Protein for PROTAC
  • LYTACs
  • Molecular Glues
  • PROTAC Linkers
  • PROTAC-Linker Conjugates for PAC
  • PROTACs
  • SNIPERs
  • Target Protein Ligand-Linker Conjugates
Protein Tyrosine Kinase/RTK
  • Ack1
  • Anaplastic lymphoma kinase (ALK)
  • Bcr-Abl
  • BMX Kinase
  • Btk
  • c-Fms
  • c-Kit
  • c-Met/HGFR
  • Discoidin Domain Receptor
  • DYRK
  • EGFR
  • Ephrin Receptor
  • FAK
  • FGFR
  • FLT3
  • IGF-1R
  • Insulin Receptor
  • Itk
  • JAK
  • PDGFR
  • Pyk2
  • RET
  • More...
Stem Cell/Wnt
  • Casein Kinase
  • ERK
  • Gli
  • GSK-3
  • Hedgehog
  • Hippo (MST)
  • JAK
  • Notch
  • Oct3/4
  • PKA
  • Porcupine
  • ROCK
  • sFRP-1
  • Smo
  • STAT
  • TGF-beta/Smad
  • Wnt
  • YAP
  • β-catenin
  • γ-secretase
TGF-beta/Smad
  • PKC
  • ROCK
  • TGF-beta/Smad
  • TGF-β Receptor
Vitamin D Related/Nuclear Receptor
  • Androgen Receptor
  • Estrogen Receptor/ERR
  • Glucocorticoid Receptor
  • LXR
  • Mineralocorticoid Receptor
  • PPAR
  • Progesterone Receptor
  • RAR/RXR
  • REV-ERB
  • ROR
  • Thyroid Hormone Receptor
  • VD/VDR
Others
  • Amino Acid Derivatives
  • Biochemical Assay Reagents
  • Fluorescent Dye
  • Isotope-Labeled Compounds
  • Others
Cytokines and Growth Factors
Immune Checkpoint Proteins
CAR-T related Proteins
CD Antigens
Fc Receptors
Receptor Proteins
Enzymes & Regulators
Complement System
Ubiquitin Related Proteins
Viral Proteins
Biotinylated Proteins
Fluorescent-labeled Proteins
GMP-grade Proteins
Animal-free Recombinant Proteins
重组蛋白定制
定制合成服务
ADC 相关定制服务
PROTAC 相关定制服务
MCE 试剂盒
分子生物学
  • • PCR & qPCR
  • • RT-PCR
  • • 核酸电泳
  • • 载体构建
  • • 核酸提取与纯化
  • • 限制性核酸内切酶
  • • 耗材
蛋白生物学
  • • 蛋白样本制备
  • • 蛋白纯化
  • • 蛋白电泳、WB
细胞生物学
  • • 细胞培养
  • • 细胞分析
  • • 3D 细胞培养
点击化学 (Click Chemistry)
GMP Small Molecules
诱导疾病模型产品
  • Cytokines and Growth Factors 细胞因子和生长因子
  • Immune Checkpoint Proteins 免疫检查点蛋白
  • CAR-T related Proteins CAR-T 相关蛋白
  • CD Antigens CD 抗原
  • Fc Receptors Fc 受体蛋白
  • Receptor Proteins 受体蛋白
  • Enzymes & Regulators 酶和调节子
  • Complement System 补体系统
  • Ubiquitin Related Proteins 泛素相关蛋白
  • Viral Proteins 病毒蛋白
  • Biotinylated Proteins 生物素标记蛋白
  • Fluorescent-labeled Proteins 荧光标记蛋白
  • GMP-grade Proteins GMP 级蛋白
  • Animal-free Recombinant Proteins 无动物成分重组蛋白
  • Others 其他
  • View More
Cytokines and Growth Factors
  • Interleukin & Receptors
  • Interferon & Receptors
  • Chemokine & Receptors
  • TNF Superfamily
  • CSF & Receptors
  • TGF-beta Superfamily
  • PDGFs & PDGFRs
  • VEGF & VEGFR
  • EGF Superfamily
  • FGF Family
  • HGF & Receptors
  • Neurotrophic Factors
  • Ephrin/Eph Family
  • Angiopoietins
  • IGF family
  • Peptide Hormone & Neuropeptides
Immune Checkpoint Proteins
  • Inhibitory Checkpoint Molecules
  • Stimulatory Immune Checkpoint Molecules
  • Butyrophilins
CAR-T related Proteins
  • B Cell Maturation Antigen (BCMA)
  • FLK-1/VEGFR-2
  • B7-H3
  • CD4
  • CD19
  • CD123
  • CD138/Syndecan-1
  • Epithelial Cell Adhesion Molecule (EpCAM)
  • Folate Receptor 1
  • GPC-3
  • Guanylate Cyclase 2C
  • ErbB2/HER2
  • ErbB3/HER3
  • c-Met/HGFR
  • MSLN
  • CA-125
  • ROR1
  • CEACAM-5
  • Natural Killer Group 2, Member D (NKG2D)
  • Prostate Specific Membrane Antigen
  • CRACC/SLAMF7
  • TROP-2
  • Siglec-6
  • Folate Receptor alpha (FR-alpha)
  • CD33
  • CD70
  • CD138/Syndecan-1
  • CD138/Syndecan-1
  • Nectin-4
  • Carbonic Anhydrase 9 (CA IX)
  • EGFR
  • FLK-1/VEGFR-2
  • CD7
  • CD20
  • Siglec-2/CD22
  • CD30
  • CD38
  • MUC-1/CD227
CD Antigens
  • T Cell CD Proteins
  • B Cell CD Proteins
  • NK Cell CD Proteins
  • Macrophage CD Proteins
  • Monocyte CD Proteins
  • Stem Cell CD Proteins
  • Platelet CD Proteins
  • Erythrocyte CD Proteins
  • Dendritic Cell CD Proteins
  • Epithelial cell CD Proteins
  • Endothelial cell CD Proteins
  • Signal Transduction-related CD Proteins
  • Cell Adhesion-related CD Proteins
Fc Receptors
  • Fc-gamma Receptor
  • FcRn
  • Fc-epsilon Receptor
  • Fc alpha/mu Receptor
  • Polymeric Immunoglobulin Receptor
  • FcμR
  • Fc Receptor-like Proteins
  • Immunoglobulin Fc Region
  • Fc alpha RI/CD89
Receptor Proteins
  • Receptor Tyrosine Kinases
  • Receptor Serine/Threonine Kinases
  • Receptor Tyrosine Phosphatase
  • Receptor Guanylyl Cyclase Family
  • Cell Adhesion Molecules (CAMs)
  • G-Protein-Coupled Receptors (GPCRs)
  • Nuclear Receptor Superfamily
  • Pattern Recognition Receptors
  • Notch family
  • Siglec
  • Leukocyte Immunoglobin-like Receptors
  • Killer-Cell Immunoglobulin-like Receptors
Enzymes & Regulators
  • Oxidoreductases (EC 1)
  • Transferases (EC 2)
  • Hydrolases (EC 3)
  • Lyases (EC 4)
  • Isomerases (EC 5)
  • Ligases (EC 6)
  • Translocases (EC 7)
  • Matrix Metalloproteinases
  • ADAMs/ADAMTSs
  • Cathepsin
  • Carboxypeptidase
  • Angiotensin-converting Enzymes
  • Caspase
  • Carbonic Anhydrase
  • Serine/Threonine Kinase Proteins
  • Protein Tyrosine Kinases
  • Phosphatase
  • Topoisomerase
  • Protease Inhibitors
  • Protein Kinase Inhibitor Peptide (PKI)
  • Cyclin-Dependent Kinase Inhibitor Proteins
  • Cystatin Family
Complement System
  • Complement Component 1
  • Complement Component 2
  • Complement Component 3
  • Complement Component 4
  • Complement Component 5
  • Complement Component 6
  • Complement Component 7
  • Complement Component 8
  • Mannose-binding Protein
  • MASP-1
  • MASP-2
  • Complement Regulatory Proteins
  • Complement Receptor
Ubiquitin Related Proteins
  • Ubiquitin/UBLs
  • Ubiquitin Enzymes
  • Deubiquitinase
Viral Proteins
  • SARS-CoV-2 Proteins
  • Zika Virus Proteins
  • RSV Proteins
  • Hepatitis C Virus Proteins
  • Hepatitis B Virus Proteins
  • HIV Proteins
  • HPV Proteins
  • Influenza Viruses Proteins
  • Dengue Virus Proteins
  • Ebola Virus Proteins
  • Bacterial/Fungal Proteins
Biotinylated Proteins
Fluorescent-labeled Proteins
GMP-grade Proteins
Animal-free Recombinant Proteins
Others
  • 分子生物学
  • •
    PCR & qPCR
  • •
    RT-PCR
  • •
    核酸电泳
  • •
    载体构建
  • •
    核酸提取与纯化
  • •
    限制性核酸内切酶
  • •
    耗材
  • 蛋白生物学
  • •
    蛋白样本制备
  • •
    蛋白纯化
  • •
    蛋白电泳、WB
  • 细胞生物学
  • •
    细胞培养
  • •
    细胞分析
  • •
    3D 细胞培养
  • View More
分子生物学
PCR & qPCR
  • PCR
  • 荧光定量 PCR
RT-PCR
  • RNA 酶抑制剂
  • 反转录试剂盒
核酸电泳
  • 核酸胶染料
  • 琼脂糖
  • 上样&电泳缓冲液
  • DNA Marker
载体构建
  • 无缝克隆试剂盒
核酸提取与纯化
  • 基因组提取纯化
  • 质粒提取纯化
限制性核酸内切酶
耗材
蛋白生物学
蛋白样本制备
  • 细胞裂解
  • 洗涤缓冲液
  • 蛋白酶抑制剂 Cocktail
  • 磷酸酶抑制剂 Cocktail
  • 去乙酰化酶抑制剂Cocktail
  • 激酶抑制剂 Cocktail
蛋白纯化
  • 磁力架
  • 磁珠
  • 亲和层析柱
  • 琼脂糖凝胶珠
  • 平衡缓冲液
  • 结合/洗涤缓冲液
蛋白电泳、WB
  • 电泳缓冲液
  • 蛋白 Marker
  • 转膜缓冲液
  • 封闭缓冲液
  • 结合/洗涤缓冲液
  • 化学显色
  • 上样缓冲液
细胞生物学
细胞培养
  • 细胞转染
  • 支原体清除
  • 无菌抗生素溶液
  • 细胞冻存
  • CEPT cocktail
  • 胎牛血清
  • 平衡盐缓冲液
  • 细胞培养添加剂
细胞分析
  • 细胞增殖与毒性检测
  • 报告基因检测
  • 细胞骨架检测
  • 细胞凋亡与细胞周期检测
  • 抗荧光淬灭剂
  • 线粒体分离
  • 外泌体提取、纯化与鉴定
3D 细胞培养
  • 基质胶
  • 类器官培养基

Lomustine (CCNU; NSC 79037) is a DNA alkylating agent. Lomustine (CCNU, 0-250 μM) is cytotoxic to the U87-MG cells expressing tumor-derived mutant IDH1, and has little effect on the expression of wild-type IDH1. The combination of Lomustine and procarbazine or vincristine has no additive effect on the killing of cells expressing mutant or wild-type IDH1. Moreover, overexpression of either ALKBH2 or ALKBH3 partially reduces the death HT1080 cells exposed to Lomustine [1] . Lomustine (CCNU) suppresses U87-MG growth with an ED50 of 68.1 μM. Lomustine (CCNU) (30, 40 μM) in combination with docosahexaenoic acid (DHA) darmatically inhibits 2 additional human-derived glioblastoma cell lines, and induces U87-MG apoptosis and necrosis. Lomustine (30 μM) causes G2/M arrest [2] . Lomustine (CCNU) reduces the viability of F98 rat orthotopic glioma cells and Tu-2449 mouse glioma cell line, with IC 50 s of 20.8 µM and 18.6 µM, respectively [3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lomustine (CCNU; NSC 79037) (30 mg/kg) in combination with Toca 511 + 5-FC prolongs survival in rats bearing F98 tumor cells. Lomustine (CCNU) (30 mg/kg) combined with Toca-511 + 5-FC also exhibits antitumor activity in the B6C3F1 mice bearing Tu-2449 glioma cells [3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

[1]. Wang P, et al. Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 2015 Dec 22;13(11):2353-2361. [Content Brief]

[2]. Harvey KA, et al. Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines. J Neurosurg. 2015 Mar;122(3):547-56. [Content Brief]

[3]. Yagiz K, et al. Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models. Neuro Oncol. 2016 Oct;18(10):1390-401. [Content Brief]

Initially, cells (5000 cells/well) are cultured in 96-well flat-bottom plates overnight in complete medium to establish a linear growth rate. Spent medium is replaced with new medium supplemented with 2% FBS and varying treatments (100 μL total volume/well). Ethanol-supplemented cells (< 0.5%) serve as the vehicle control. Cells are maintained at 37°C in 5% CO 2 in a humidified atmosphere for 24 hours prior to assessment of cell growth with the WST-1 assay reagent. Medium alone combined with the WST-1 assay reagent establishes nonspecific values that are subtracted from the experimental optical density (OD) readings (OD at 450 nm). Vehicle control OD readings serve as standard proliferative potential normalized to 100%. The proliferation index is calculated by dividing the average OD treatment reading by the average OD vehicle reading and multiplying by 100 [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mice [3]
Groups of B6C3F1 mice receive PBS or 5-FC only as a control during the study (n = 8 per group). One group of mice (Lomustine Day 1 + PBS) receive one dose of Lomustine (30 mg/kg) on day 1 and a total of six cycles of PBS (800 μL/day, BID for 4 consecutive days every 10 days). The rest of the mice receive 5-FC (500 mg/kg/dose, IP, BID) for 4 consecutive days, plus Lomustine at day 1 (Lomustine (CCNU) Day 1 + 5-FC) or day 43 (Lomustine (CCNU) Day 43 + 5-FC). Cycles of 4-days on, 10-days off 5-FC or PBS are repeated a total of 6 times. Each experiment is terminated at the end of the last 5-FC treatment. All tissues are collected and saved for histopathology. Toxicity in groups receiving Lomustine is compared to the groups receiving PBS or 5-FC alone or in combination with 5-FC at designated time points [3] .
Rats [3]
Groups of rats receive PBS or 5-FC only as controls during the study (n = 8 per group). One group of rats (Lomustine (CCNU) Day 1 + PBS) receive one dose of Lomustine (30 mg/kg) at day 1 and a total of six cycles of PBS (8 mL/day, BID). The rest of the rats receive 5-FC (500 mg/kg/dose, IP, BID) for 5 consecutive days, followed by 2 days off drug, plus Lomustine on day 1 (Lomustine (CCNU) Day 1 + 5-FC) or day 22 ( Lomustine (CCNU) Day 22 + 5-FC ). Cycles of 5-days on, 2-days off 5-FC or PBS are repeated a total of 6 times [3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

[1]. Wang P, et al. Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 2015 Dec 22;13(11):2353-2361. [Content Brief]

[2]. Harvey KA, et al. Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines. J Neurosurg. 2015 Mar;122(3):547-56. [Content Brief]

[3]. Yagiz K, et al. Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models. Neuro Oncol. 2016 Oct;18(10):1390-401. [Content Brief]

[1]. Wang P, et al. Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 2015 Dec 22;13(11):2353-2361.

[2]. Harvey KA, et al. Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines. J Neurosurg. 2015 Mar;122(3):547-56.

[3]. Yagiz K, et al. Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models. Neuro Oncol. 2016 Oct;18(10):1390-401.

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C 1 V 1 = C 2 V 2

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