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  • 1 Microbiology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK. p.louis@abdn.ac.uk.
  • 2 Microbiology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.
  • 3 UMR Physiologie des Adaptations Nutritionnelles, Université de Nantes, INRA, HNB1- CHU-Hotel DIEU, Place Alexis Ricordeau, 44093, NANTES Cedex 1, France.
  • 1 Microbiology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK. p.louis@abdn.ac.uk.
  • 2 Microbiology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.
  • 3 UMR Physiologie des Adaptations Nutritionnelles, Université de Nantes, INRA, HNB1- CHU-Hotel DIEU, Place Alexis Ricordeau, 44093, NANTES Cedex 1, France.
  • During the last century, human nutrition has evolved from the definition of our nutritional needs and the identification of ways to meet them, to the identification of food components that can optimise our physiological and psychological functions. This development, which aims to ensure the welfare, health and reduced susceptibility to disease during life, gave birth to the concept of "functional foods". In this context, there is an increasing interest in the physiological effects induced by the dense and diverse microbiota which inhabits the human colon and whose development depends on the fermentation of undigested food residues. Thus, much research aims at identifying ways to guide these impacts in order to benefit the health of the host. It is in this context that the concept of "prebiotics" was developed in the 1990s. Since then, prebiotics have stimulated extensive work in order to clarify their definition, their nature and their physiological properties in accordance with the evolution of knowledge on the intestinal microbiota. However many questions remain open about their specificities, their mechanism(s) of action and therefore the relevance of their current categorisation. Blaut M. Eur J Nutr. 2002 Nov;41 Suppl 1:I11-6. doi: 10.1007/s00394-002-1102-7. Eur J Nutr. 2002. PMID: 12420111 Review. Shortt C, et al. Eur J Nutr. 2018 Feb;57(1):25-49. doi: 10.1007/s00394-017-1546-4. Epub 2017 Oct 30. Eur J Nutr. 2018. PMID: 29086061 Free PMC article. Review. Guarino MPL, et al. Nutrients. 2020 Apr 9;12(4):1037. doi: 10.3390/nu12041037. Nutrients. 2020. PMID: 32283802 Free PMC article. Review. Flint HJ. Nutr Rev. 2012 Aug;70 Suppl 1:S10-3. doi: 10.1111/j.1753-4887.2012.00499.x. Nutr Rev. 2012. PMID: 22861801 Review. Del Barrio M, et al. Int J Mol Sci. 2023 Mar 24;24(7):6123. doi: 10.3390/ijms24076123. Int J Mol Sci. 2023. PMID: 37047094 Free PMC article. Review. Bamigbade GB, et al. Molecules. 2022 Sep 13;27(18):5947. doi: 10.3390/molecules27185947. Molecules. 2022. PMID: 36144679 Free PMC article. Review. Kim K, et al. Front Immunol. 2022 Aug 5;13:885253. doi: 10.3389/fimmu.2022.885253. eCollection 2022. Front Immunol. 2022. PMID: 35990617 Free PMC article. Review. Bilal M, et al. Front Nutr. 2022 Jul 22;9:931458. doi: 10.3389/fnut.2022.931458. eCollection 2022. Front Nutr. 2022. PMID: 35938108 Free PMC article. Review. Thye AY, et al. Nutrients. 2022 Apr 14;14(8):1647. doi: 10.3390/nu14081647. Nutrients. 2022. PMID: 35458209 Free PMC article. Review.